It opens K+ and Ca++ channels, causes membrane hyperpolarization and inhibits conduction of pain impulses. Analgesic effect is due to reduction of nociceptive activity and enhancement of antinociceptive system of the body. Tramadol hydrochloride exhibits anti-cough effect Reviews Tramadol. When used in therapeutic doses, tramadol hydrochloride does not inhibit breathing and does not affect intestinal motility.
